Monoclonal antibody preparation of ADC payload
ADC drugs are multi-domain molecules composed of monoclonal antibodies (mAbs), linkers, and small molecule cytotoxins. With the increasing number of ADC drugs, the clinical immunogenicity risk of ADC drugs has been increasingly valued by the industry. The design and development of neutralizing antibody detection methods for ADC drugs are different from those of conventional antibody drugs and present significant challenges.
ADC drugs are composed of monoclonal antibodies (mAb), linkers, and small molecule cytotoxins. Multi-domain Molecules. With the increase in ADC drugs, the clinical immunogenicity risk of ADC drugs has been increasingly valued by the industry. The design and development of neutralizing antibody detection methods for ADC drugs are different from conventional antibody drugs and present significant challenges.
Antibody Use
Monoclonal antibodies of small molecule cytotoxins in antibody-drug conjugates (ADC) can be used for PK analysis of ADC drugs and qualitative analysis of the conjugation DAR value; providing key antibody reagents for ADC drug development and accelerating the R&D process of ADC drugs.
Features and Advantages
Strong uniqueness: Based on the company's unique antigen-antibody preparation technology, high-affinity, high-specificity, high-sensitivity, and high-stability anti-ADC payload monoclonal antibodies have been developed;
Good effect: The monoclonal antibody against ADC small molecule cytotoxins has been provided by Xi Chang Biology to many leading domestic ADC drug companies, and the product shows good results in experimental data detection;
Complete range of products: DM1, MMAE, SN-38, Dxd, irinotecan, budesonide, and other commonly used toxins and hormones, as well as special payloads modified by customers;
Wide application: It can identify the small molecule part of antibody-drug conjugates and can detect the conjugation value of antibodies and small molecule toxins, as well as PK/PD blood sample detection required for animal experiments and human clinical trials.
Antibody Display
Dose response curve shows that the EC50 of Anti-DXD mAb is 0.03694 μg/mL.
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