Anti-MMAE monoclonal antibody

Product Number: XC994997-100µg English Name: Anti-MMAE mAb Chinese Name: Anti-MMAE Monoclonal Antibody
  • Commodity name: Anti-MMAE monoclonal antibody

Detailed description

  • Product Description
  • Product Specifications

    Product Number XC994997-100µg
    English name Anti-MMAE mAb
    Chinese name Anti-MMAE monoclonal antibody
    Antibody source Mouse
    Clone Type Monoclonal
    Physical State

    Liquid

    Concentration 1mg/mL
    Subtype IgG
    Expression system Hybridoma
    Purification method affinity purified by Protein G
    Buffer solution 0.2 μm filtered in PBS, pH 7.4
    Purity ≥95% as determined by SDS-PAGE; ≥98% as determined by SEC-HPLC
    Activity EC50=0.01415 μg/mL by ELISA
    Application ELISA, Sandwich ELISA, Competitive ELISA

    Storage conditions

    Aliquot and store at -20°C to -80°C,Avoid repeat freeze-thaw cycles.

    Precautions

    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    Product Introduction

    MMAE, or monomethyl auristatin E, is a potent cytotoxic agent commonly used in the development of antibody-drug conjugates (ADCs) for targeted cancer therapy. It is an antimitotic agent which inhibits cell division by blocking the polymerization of tubulin. Monoclonal anti-MMAE antibody, is produced from a hybridoma which was obtained from a mouse immunized with MMAE.

    Image data

    SDS-PAGE
    Anti-MMAE mAb on SDS-PAGE under reduced condition. The purity is 94.7%;
    Anti-MMAE mAb on SDS-PAGE under non-reduced condition. The purity is 97.6%.

    SEC-HPLC
    The purity of Anti-MMAE mAb is 98.0% as determined by SEC-HPLC.

    ELISA Data
    Dose response curve shows that the EC50 of Anti-MMAE mAb is 0.01415 μg/mL.

Documentary materials

Image Name

Anti-MMAE Monoclonal Antibody COA

Keywords:

Reference drug | Anti-drug antibodies | Instrument | Reagent

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