Anti-DM1 monoclonal antibody

Product Number: XC996997-100µg English Name: Anti-DM1 mAb Chinese Name: Anti-DM1 Monoclonal Antibody
  • Commodity name: Anti-DM1 monoclonal antibody

Detailed description

  • Product Description
  • Product Specifications

    Product Number XC996997-100µg
    English name Anti-DM1 mAb
    Chinese name Anti-DM1 monoclonal antibody
    Antibody source Mouse
    Clone Type Monoclonal
    Physical State Liquid
    Concentration IgG
    Subtype Hybridoma
    Expression system affinity purified by Protein G
    Purification method 0.2 μm filtered in PBS, pH 7.4
    Buffer solution 1mg/mL
    Purity >95% as determined by SDS-PAGE;>95% as determined by SEC-HPLC
    Activity EC50=0.01917 μg/mL by ELISA
    Application ELISA, Sandwich ELISA, Competitive ELISA

    Storage conditions

    Aliquot and store at -20°C to -80°C,Avoid repeat freeze-thaw cycles.

    Precautions

    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    Product Introduction

    DM1, also known as maytansine, is a microtubulin inhibitor, potentially conjugated with monoclonal antibodies to form antibody-drug conjugates(ADCs). DM1 as the toxin component of ADCs, exhibits strong anti-tumor activity by inhibiting cell division and inducing apoptosis. Monoclonal anti-DM1 antibody, is produced from a hybridoma which was obtained from a mouse immunized with DM-1.

    Image data

    SDS-PAGE
    Anti-DM1 mAb on SDS-PAGE under reduced condition. The purity is 93.4%;
    Anti-DM1 mAb on SDS-PAGE under non-reduced condition. The purity is 98.0%.

    SEC-HPLC
    The purity of Anti-DM1 mAb is 96.8% as determined by SEC-HPLC.

    ELISA Data
    Dose response curve shows that the EC50 of Anti-DM1 mAb is 0.01917μg/mL.

Documentary materials

Image Name

Anti-DM1 Monoclonal Antibody COA

Keywords:

Reference drug | Anti-drug antibodies | Instrument | Reagent

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