SDS-PAGE
Anti-DM1 mAb on SDS-PAGE under reduced condition. The purity is 93.4%；
Anti-DM1 mAb on SDS-PAGE under non-reduced condition. The purity is 98.0%.
Anti-DM1 monoclonal antibody
Product Number: XC996997-100µg
English Name: Anti-DM1 mAb
Chinese Name: Anti-DM1 Monoclonal Antibody
- Commodity name： Anti-DM1 monoclonal antibody
Detailed description
- Product Description
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Product Specifications
Product Number XC996997-100µg English name Anti-DM1 mAb Chinese name Anti-DM1 monoclonal antibody Antibody source Mouse Clone Type Monoclonal Physical State Liquid Concentration IgG Subtype Hybridoma Expression system affinity purified by Protein G Purification method 0.2 μm filtered in PBS, pH 7.4 Buffer solution 1mg/mL Purity ＞95% as determined by SDS-PAGE；＞95% as determined by SEC-HPLC Activity EC50=0.01917 μg/mL by ELISA Application ELISA, Sandwich ELISA, Competitive ELISA Storage conditions
Aliquot and store at -20°C to -80°C,Avoid repeat freeze-thaw cycles.
Precautions
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Product Introduction
DM1, also known as maytansine, is a microtubulin inhibitor, potentially conjugated with monoclonal antibodies to form antibody-drug conjugates(ADCs). DM1 as the toxin component of ADCs, exhibits strong anti-tumor activity by inhibiting cell division and inducing apoptosis. Monoclonal anti-DM1 antibody, is produced from a hybridoma which was obtained from a mouse immunized with DM-1.
Image data
SEC-HPLC
The purity of Anti-DM1 mAb is 96.8% as determined by SEC-HPLC.
ELISA Data
Dose response curve shows that the EC50 of Anti-DM1 mAb is 0.01917μg/mL.
Documentary materials
Keywords:
Reference drug | Anti-drug antibodies | Instrument | Reagent
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