Recombinant human IL-10 protein (his-tag)
- Commodity name： Recombinant human IL-10 protein (his-tag)
Details Description
- Product Description
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Product Parameters
Product Number XC986997-500μg English Name Recombinant Human IL-10 Protein Chinese Name Recombinant Human IL-10 Protein Alias CSIF; IL10; IL10A; Interleukin-10; TGIF Gene ID 3586 Research Area Neuroinflammation Protein Source Human Expression Host E. coli Protein Tag N-terminal 6xHis-tag Protein Purity >95% purity by SDS-PAGE under reduced conditions. Expression Region Human IL-10 Protein is expressed from E. coli cells. It contains AA （Ser 19 - Asn 178） (Accession # P22301), This protein was fused with the His tag at the N-terminus Predicted Molecular Weight The protein has a calculated MW of 18.5 kDa State Liquid Buffer 0.2 μm filtered in PBS, pH 7.4, 50% glycerol Storage Conditions
Aliquot and store at -20°C to -80°C,Avoid repeat freeze-thaw cycles.
Notes
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Product Introduction
IL-10 is an anti-inflammatory cytokine that belongs to the IL-10 family. It is produced by a variety of cell lines, including T-cells, macrophages, mast cells, and other cell types, while it is produced primarily by monocytes and to a lesser extent by lymphocytes. IL-10 is mainly expressed in monocytes and Type 2 T helper cells (TH2), mast cells, CD4+CD25+Foxp3+ regulatory T cells, and also in a certain subset of activated T cells and B cells. IL-10 has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. The importance of interleukin 10 for counteracting excessive immunity in the human body is revealed by the fact that patients with Crohn's disease react favorably towards treatment with bacteria producing recombinant IL-10. IL-10 inhibits the synthesis of some cytokines, including IFN-gamma, IL-2, IL-3, TNF, and GM-CSF produced by activated macrophages and by helper T-cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen-presenting cells. However, it is also stimulatory towards certain T cells and mast cells and stimulates B cell maturation and antibody production.
Image Data
SDS-PAGE Electrophoresis
Lane M: Protein marker Lane 1: Reduced sample
Documents
Keywords:
Reference Drug | Antibody Drug | Instrument | Reagent
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