Recombinant human IL-18 protein (his-tag)
- Commodity name： Recombinant human IL-18 protein (his-tag)
Details Description
- Product Description
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Product Parameters
Product Number XC987997-500μg English Name Recombinant Human IL-18 Protein Chinese Name 重组人IL-18 蛋白 Alias IGIF; IL-18; IL-1g; IL1F4; Interleukin 18 Gene ID 3606 Research Field Immunology Protein Source Human Expression Host E. coli Protein Tag N-terminal 6xHis-tag Protein Purity >95% purity by SDS-PAGE under reduced conditions Expression Region Human IL-18 Protein is expressed from E. coli cells. It contains AA( Tyr 37 - Asp 193 )(Accession # Q14116), This protein was fused with the His tag at the N-terminus. Predicted Molecular Weight The protein has a calculated MW of 18 kDa State Liquid Buffer 0.2 μm filtered in PBS, pH 7.4, 50% glycerol Storage Conditions
Aliquot and store at -20°C to -80°C,Avoid repeat freeze-thaw cycles.
Notes
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Product Introduction
Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of IL-18 and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. IL-18 is an IL-1−like cytokine that requires cleavage with caspase-1 to become active, was found to increase IgE production in a CD4+ T cells-, IL-4− and STAT6−dependent fashion. IL-18 and T cell receptor−mediated stimulation could induce naïve CD4+ T cells to develop into IL-4−producing cells in vitro. Thus, caspase-1 and IL-18 may be critical in regulation of IgE production in vivo, providing a potential therapeutic target for allergic disorders. IL-18 production in primary synovial cultures and purified synovial fibroblasts was, in turn, upregulated by TNF-α and IL1β, suggesting that monokine expression can feed back to promote Th1 cell development in synovial membrane. Besides, synergistic combinations of IL-18, IL-12, and IL-15 may be of importance in sustaining both Th1 responses and monokine production in RA.
Image Data
SDS-PAGE Electrophoresis
Lane M: Protein marker Lane 1: Reduced sample
Documents
Keywords:
Reference Drug | Antibody Drug | Instrument | Reagent
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